Gene Information
Gene NameGDE1
OrganismHomo sapiens (Human)
Gene Length331
Protein NamesGlycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000006007 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NZC3
Gene CardGDE1
Uniprot IDQ9NZC3
PfamPF03009
In ASDno
Allosteric Predictionno (-0.79940713)
Ortholog in AnimalsAlpaca_ GDE1 ( ortholog_one2one )
Dog_ GDE1 ( ortholog_one2many )
GuineaPig_ GDE1 ( ortholog_one2one )
Macaque_ GDE1 ( ortholog_one2one )
Mouse_ Gde1 ( ortholog_one2one )
Pig_ GDE1 ( ortholog_one2one )
Rat_ Gde1 ( ortholog_one2one )
Rabbit_ GDE1 ( ortholog_one2one )
OhnologsNA
ParalogsGDPD4, GDPD2, GDPD1, GDPD5, GDPD3
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10760272}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2072086  rs34137361 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:Q9JL55};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55};
Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250|UniProtKB:Q9JL55}.
Mouse PG classificationNA
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