| Gene Information | |
|---|---|
| Gene Name | GC |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf) |
| Target Name | vitamin d-binding protein |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000145321 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02774 |
| Gene Card | GC |
| Uniprot ID | P02774 |
| Pfam | PF00273; PF09164 |
| In ASD | no |
| Allosteric Prediction | yes (0.895387611) |
| Ortholog in Animals | Alpaca_ GC ( ortholog_one2one ) Dog_ GC ( ortholog_one2one ) GuineaPig_ GC ( ortholog_one2one ) Macaque_ GC ( ortholog_one2one ) Mouse_ Gc ( ortholog_one2one ) Pig_ GC ( ortholog_one2one ) Rat_ Gc ( ortholog_one2one ) Rabbit_ GC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AFM, AFP, ALB |
| Tissue | liver, gall.bladder |
| Tissue Specificity | Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. {ECO:0000269|PubMed:20079467, ECO:0000269|PubMed:2416779, ECO:0000305|PubMed:16302727}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J78 (X-ray 2.31A ) 1J7E (X-ray 2.55A ) 1KW2 (X-ray 2.15A ) 1KXP (X-ray 2.10A ) 1LOT (X-ray 2.50A ) 1MA9 (X-ray 2.40A ) |
| DBSNP | rs7041 rs4588 rs9016 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:2423133}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |