Gene Information
Gene NameGCK
OrganismHomo sapiens (Human)
Gene Length465
Protein NamesHexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D)
Target Nameglucokinase
Target TypeNA
Gene Age1292 ( ENSG00000106633 )
Evolutionary StageEuk+Bac
AlphaFoldDBP35557
Gene CardGCK
Uniprot IDP35557
PfamPF00349; PF03727
In ASDyes
Allosteric Predictionyes (1.769025306)
Ortholog in AnimalsAlpaca_ GCK ( ortholog_one2one )
Dog_ GCK ( ortholog_one2one )
GuineaPig_ GCK ( ortholog_one2one )
Macaque_ GCK ( ortholog_one2one )
Mouse_ Gck ( ortholog_one2one )
Pig_ GCK ( ortholog_one2one )
Rat_ Gck ( ortholog_one2one )
OhnologsHKDC1, HK1, HK3
ParalogsHK1, HK3, HKDC1, HK2
Tissuepituitary.gland
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1V4S  (X-ray  2.30A  1V4T  (X-ray  3.40A  3A0I  (X-ray  2.20A  3F9M  (X-ray  1.50A  3FGU  (X-ray  2.15A  3FR0  (X-ray  2.70A  3GOI  (X-ray  2.52A  3H1V  (X-ray  2.11A  3ID8  (X-ray  2.40A  3IDH  (X-ray  2.14A  3IMX  (X-ray  2.00A  3QIC  (X-ray  2.20A  3S41  (X-ray  2.18A  3VEV  (X-ray  1.80A  3VEY  (X-ray  2.25A  3VF6  (X-ray  1.86A  4DCH  (X-ray  1.79A  4DHY  (X-ray  2.38A  4ISE  (X-ray  1.78A  4ISF  (X-ray  2.09A  4ISG  (X-ray  2.64A  4IWV  (X-ray  2.10A  4IXC  (X-ray  2.00A  4L3Q  (X-ray  2.70A  4LC9  (X-ray  3.40A  4MLE  (X-ray  2.60A  4MLH  (X-ray  2.90A  4NO7  (X-ray  1.70A  4RCH  (X-ray  2.30A  5V4W  (X-ray  2.39A  5V4X  (X-ray  2.08A  6E0E  (X-ray  2.70A  6E0I  (X-ray  1.90A  7T78  (X-ray  2.40A  7T79  (X-ray  2.40A 
DBSNP rs202091228  rs116093166  rs762263694  rs794727236  rs1486280029  rs764232985  rs1486280029  rs267601516  rs373418736  rs193922289  rs2096281827  rs1554335761  rs193922292  rs1338970607  rs1176659689  rs104894010  rs193922297  rs2096280050  rs1554335566  rs2096278847  rs587780344  rs587780345  rs751279776  rs193922307  rs1085307455  rs193922311  rs1562717053  rs1441649062  rs1583599303  rs80356654  rs80356654  rs104894015  rs147065275  rs193922317  rs1360415315  rs772754004  rs148311934  rs80356655  rs759421263  rs769268803  rs1554335135  rs1375656631  rs104894008  rs104894011  rs104894005  rs104894009  rs1255911887  rs1583594350  rs1000236360  rs1057521092  rs193922264  rs104894016  rs193922265  rs777870079  rs1376620210  rs1167124132  rs2096271425  rs193929375  rs193922272  rs1583591303  rs1286804191  rs758737171  rs1131691416  rs193922282  rs104894012  rs104894014 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Nucleus {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Mitochondrion {ECO:0000250|UniProtKB:P17712}. Note=Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
Mouse PG classificationLPG
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