| Gene Information | |
|---|---|
| Gene Name | GCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) |
| Target Name | glucokinase |
| Target Type | Clinical trial target |
| Gene Age | 1292 ( ENSG00000106633 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P35557 |
| Gene Card | GCK |
| Uniprot ID | P35557 |
| Pfam | PF00349; PF03727 |
| In ASD | yes |
| Allosteric Prediction | yes (1.769025306) |
| Ortholog in Animals | Alpaca_ GCK ( ortholog_one2one ) Dog_ GCK ( ortholog_one2one ) GuineaPig_ GCK ( ortholog_one2one ) Macaque_ GCK ( ortholog_one2one ) Mouse_ Gck ( ortholog_one2one ) Pig_ GCK ( ortholog_one2one ) Rat_ Gck ( ortholog_one2one ) |
| Ohnologs | HKDC1, HK1, HK3 |
| Paralogs | HK1, HK3, HKDC1, HK2 |
| Tissue | pituitary.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1V4S (X-ray 2.30A ) 1V4T (X-ray 3.40A ) 3A0I (X-ray 2.20A ) 3F9M (X-ray 1.50A ) 3FGU (X-ray 2.15A ) 3FR0 (X-ray 2.70A ) 3GOI (X-ray 2.52A ) 3H1V (X-ray 2.11A ) 3ID8 (X-ray 2.40A ) 3IDH (X-ray 2.14A ) 3IMX (X-ray 2.00A ) 3QIC (X-ray 2.20A ) 3S41 (X-ray 2.18A ) 3VEV (X-ray 1.80A ) 3VEY (X-ray 2.25A ) 3VF6 (X-ray 1.86A ) 4DCH (X-ray 1.79A ) 4DHY (X-ray 2.38A ) 4ISE (X-ray 1.78A ) 4ISF (X-ray 2.09A ) 4ISG (X-ray 2.64A ) 4IWV (X-ray 2.10A ) 4IXC (X-ray 2.00A ) 4L3Q (X-ray 2.70A ) 4LC9 (X-ray 3.40A ) 4MLE (X-ray 2.60A ) 4MLH (X-ray 2.90A ) 4NO7 (X-ray 1.70A ) 4RCH (X-ray 2.30A ) 5V4W (X-ray 2.39A ) 5V4X (X-ray 2.08A ) 6E0E (X-ray 2.70A ) 6E0I (X-ray 1.90A ) 7T78 (X-ray 2.40A ) 7T79 (X-ray 2.40A ) |
| DBSNP | rs202091228 rs116093166 rs762263694 rs794727236 rs1486280029 rs764232985 rs1486280029 rs267601516 rs373418736 rs193922289 rs2096281827 rs1554335761 rs193922292 rs1338970607 rs1176659689 rs104894010 rs193922297 rs2096280050 rs1554335566 rs2096278847 rs587780344 rs587780345 rs751279776 rs193922307 rs1085307455 rs193922311 rs1562717053 rs1441649062 rs1583599303 rs80356654 rs80356654 rs104894015 rs147065275 rs193922317 rs1360415315 rs772754004 rs148311934 rs80356655 rs759421263 rs769268803 rs1554335135 rs1375656631 rs104894008 rs104894011 rs104894005 rs104894009 rs1255911887 rs1583594350 rs1000236360 rs1057521092 rs193922264 rs104894016 rs193922265 rs777870079 rs1376620210 rs1167124132 rs2096271425 rs193929375 rs193922272 rs1583591303 rs1286804191 rs758737171 rs1131691416 rs193922282 rs104894012 rs104894014 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Nucleus {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:24187134}. Mitochondrion {ECO:0000250|UniProtKB:P17712}. Note=Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}. |
| Mouse PG classification | LPG |
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