| Gene Information | |
|---|---|
| Gene Name | GCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 820 |
| Protein Names | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) |
| Target Name | glucokinase |
| Target Type | Clinical trial target |
| Gene Age | 1292 ( ENSG00000106633 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q12851 |
| Gene Card | MAP4K2 |
| Uniprot ID | Q12851 |
| Pfam | PF00780; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.769025306) |
| Ortholog in Animals | Alpaca_ GCK ( ortholog_one2one ) Dog_ GCK ( ortholog_one2one ) GuineaPig_ GCK ( ortholog_one2one ) Macaque_ GCK ( ortholog_one2one ) Mouse_ Gck ( ortholog_one2one ) Pig_ GCK ( ortholog_one2one ) Rat_ Gck ( ortholog_one2one ) |
| Ohnologs | HKDC1, HK1, HK3 |
| Paralogs | HK1, HK3, HKDC1, HK2 |
| Tissue | pituitary.gland |
| Tissue Specificity | Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | LPG |
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