| Gene Information | |
|---|---|
| Gene Name | STAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 750 |
| Protein Names | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) |
| Target Name | signal transducer and activator of transcription 1 |
| Target Type | Patented-recorded target |
| Gene Age | 544 ( ENSG00000115415 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P42224 |
| Gene Card | STAT1 |
| Uniprot ID | P42224 |
| Pfam | PF00017; PF12162; PF01017; PF02864; PF02865 |
| In ASD | no |
| Allosteric Prediction | yes (0.520593208) |
| Ortholog in Animals | Alpaca_ STAT1 ( ortholog_one2one ) Dog_ STAT1 ( ortholog_one2one ) GuineaPig_ STAT1 ( ortholog_one2one ) Macaque_ STAT1 ( ortholog_one2one ) Mouse_ Stat1 ( ortholog_one2one ) Pig_ STAT1 ( ortholog_one2one ) Rat_ Stat4 ( ortholog_one2one ) Rabbit_ STAT1 ( ortholog_one2one ) |
| Ohnologs | STAT5A, STAT6, STAT3, STAT2, STAT5B |
| Paralogs | STAT2, STAT4, STAT3, STAT5B, STAT5A, STAT6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BF5 (X-ray 2.90A ) 1YVL (X-ray 3.00A ) 2KA6 (NMR - ) 3WWT (X-ray 2.00A ) 7NUF (X-ray 2.00A ) 8D3F (X-ray 2.97A ) |
| DBSNP | rs34255470 rs387906764 rs387906767 rs387906766 rs387906763 rs587777628 rs587776870 rs387906762 rs387906759 rs387906768 rs387906760 rs387906758 rs863223398 rs587777629 rs387906761 rs387906765 rs137852680 rs796065052 rs587777630 rs137852679 rs137852678 rs587777705 rs587777704 rs137852677 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426}. Nucleus {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. |
| Mouse PG classification | LPG |
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