| Gene Information | |
|---|---|
| Gene Name | GCGR |
| Organism | Homo sapiens (Human) |
| Gene Length | 477 |
| Protein Names | Glucagon receptor (GL-R) |
| Target Name | glucagon receptor |
| Target Type | Successful target |
| Gene Age | 1064 ( ENSG00000215644 ) 3 ( ENSG00000288269 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P47871 |
| Gene Card | GCGR |
| Uniprot ID | P47871 |
| Pfam | PF00002; PF02793 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000462852) |
| Ortholog in Animals | Alpaca_ GCGR ( ortholog_one2one ) GuineaPig_ GCGR ( ortholog_one2one ) Macaque_ GCGR ( ortholog_one2one ) Mouse_ Gcgr ( ortholog_one2one ) Pig_ GCGR ( ortholog_one2one ) Rat_ Gcgr ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | liver, kidney |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A83 (X-ray 1.40A ) 3CZF (X-ray 1.20A ) 4ERS (X-ray 2.64A ) 4L6R (X-ray 3.30A ) 4LF3 (X-ray 2.74A ) 5EE7 (X-ray 2.50A ) 5XEZ (X-ray 3.00A ) 6LMK (EM 3.70A ) 6LML (EM 3.90A ) 6WHC (EM 3.40A ) 6WPW (EM 3.10A ) 7V35 (EM 3.40A ) |
| DBSNP | rs1801483 rs5385 rs5387 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:30294546, ECO:0000269|PubMed:32677665, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding. {ECO:0000269|PubMed:9287038}. |
| Mouse PG classification | NA |
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