| Gene Information | |
|---|---|
| Gene Name | GCG |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] |
| Target Name | glucagon |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000115263 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01275 |
| Gene Card | GCG |
| Uniprot ID | P01275 |
| Pfam | PF00123 |
| In ASD | no |
| Allosteric Prediction | yes (0.76600382) |
| Ortholog in Animals | Alpaca_ GCG ( ortholog_one2one ) Dog_ GCG ( ortholog_one2one ) GuineaPig_ GCG ( ortholog_one2one ) Macaque_ GCG ( ortholog_one2one ) Mouse_ Gcg ( ortholog_one2one ) Pig_ GCG ( ortholog_one2one ) Rat_ Gcg ( ortholog_one2one ) Rabbit_ GCG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | pancreas |
| Tissue Specificity | [Glucagon]: Secreted in the A cells of the islets of Langerhans. {ECO:0000269|PubMed:22037645}.; [Glucagon-like peptide 1]: Secreted in the A cells of the islets of Langerhans (PubMed:22037645). Secreted from enteroendocrine L cells throughout the gastrointestinal tract (PubMed:22037645). Also secreted in selected neurons in the brain. {ECO:0000269|PubMed:22037645}.; [Glucagon-like peptide 2]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. Also secreted in selected neurons in the brain.; [Glicentin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract.; [Oxyntomodulin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BH0 (X-ray 3.00A ) 1D0R (NMR - ) 1NAU (NMR - ) 2G49 (X-ray 2.50A ) 2L63 (NMR - ) 2L64 (NMR - ) 2M5P (NMR - ) 2M5Q (NMR - ) 3IOL (X-ray 2.10A ) 4APD (NMR - ) 4ZGM (X-ray 1.80A ) 5OTU (X-ray 1.80A ) 5OTV (X-ray 2.00A ) 5OTW (X-ray 2.10A ) 5OTX (X-ray 2.00A ) 5VAI (EM 4.10A ) 5YQZ (X-ray 3.00A ) 6EDS (X-ray 3.18A ) 6LMK (EM 3.70A ) 6LML (EM 3.90A ) 6NZN (NMR - ) 6PHI (X-ray 1.10A ) 6PHJ (X-ray 1.99A ) 6PHK (X-ray 1.18A ) 6PHL (X-ray 1.44A ) 6PHO (X-ray 1.42A ) 6PHP (X-ray 1.65A ) 6VCB (EM 3.30A ) 6X18 (EM 2.10A ) 7D68 (EM 3.00A ) 7DUQ (EM 2.50A ) 7KI0 (EM 2.50A ) 7KI1 (EM 2.50A ) |
| DBSNP | rs5650 |
| Subcellular location [CC] | Secreted {ECO:0000305}.; [Glucagon-like peptide 1]: Secreted {ECO:0000269|PubMed:22037645}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |