| Gene Information | |
|---|---|
| Gene Name | GGPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 300 |
| Protein Names | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) |
| Target Name | geranylgeranyl pyrophosphate synthase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000152904 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O95749 |
| Gene Card | GGPS1 |
| Uniprot ID | O95749 |
| Pfam | PF00348 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000007013) |
| Ortholog in Animals | Alpaca_ GGPS1 ( ortholog_one2one ) Dog_ GGPS1 ( ortholog_one2one ) GuineaPig_ GGPS1 ( ortholog_one2one ) Macaque_ GGPS1 ( ortholog_one2one ) Mouse_ Ggps1 ( ortholog_one2one ) Pig_ GGPS1 ( ortholog_one2one ) Rat_ Ggps1 ( ortholog_one2one ) Rabbit_ GGPS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDSS2, PDSS1 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in testis (PubMed:9741684, PubMed:10026212). Found in other tissues to a lower extent (PubMed:9741684, PubMed:10026212). Expressed in dermal fibroblast and skeletal muscle (PubMed:32403198). {ECO:0000269|PubMed:10026212, ECO:0000269|PubMed:32403198, ECO:0000269|PubMed:9741684}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2Q80 (X-ray 2.70A ) 6C56 (X-ray 2.80A ) 6C57 (X-ray 3.50A ) 6G31 (X-ray 3.00A ) 6G32 (X-ray 3.28A ) 6R4V (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32403198}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32403198}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:32403198}. |
| Mouse PG classification | NA |
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