| Gene Information | |
|---|---|
| Gene Name | GCA |
| Organism | Homo sapiens (Human) |
| Gene Length | 217 |
| Protein Names | Grancalcin |
| Target Name | grancalcin |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000115271 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P28676 |
| Gene Card | GCA |
| Uniprot ID | P28676 |
| Pfam | PF13833 |
| In ASD | no |
| Allosteric Prediction | yes (0.45959365) |
| Ortholog in Animals | Alpaca_ GCA ( ortholog_one2one ) Dog_ GCA ( ortholog_one2one ) GuineaPig_ GCA ( ortholog_one2one ) Macaque_ GCA ( ortholog_one2one ) Mouse_ Gca ( ortholog_one2one ) Pig_ GCA ( ortholog_one2one ) Rat_ Gca ( ortholog_one2one ) |
| Ohnologs | SRI |
| Paralogs | CAPN1, PEF1, CAPN9, PDCD6, CAPN2, CAPN5, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN8, CAPN3, CAPN12, CAPNS2, CAPN11, CAPN13, CAPNS1, CAPN10, SRI |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow. {ECO:0000269|PubMed:1737748}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F4O (X-ray 2.50A ) 1F4Q (X-ray 1.90A ) 1K94 (X-ray 1.70A ) 1K95 (X-ray 1.90A ) |
| DBSNP | rs17783344 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:1530588, ECO:0000269|PubMed:1737748}. Cytoplasmic granule membrane {ECO:0000269|PubMed:1737748, ECO:0000305|PubMed:1530588}; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. {ECO:0000269|PubMed:1737748}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |