| Gene Information | |
|---|---|
| Gene Name | GC |
| Organism | Homo sapiens (Human) |
| Gene Length | 758 |
| Protein Names | Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) |
| Target Name | vitamin d-binding protein |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000145321 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P38435 |
| Gene Card | GGCX |
| Uniprot ID | P38435 |
| Pfam | PF05090 |
| In ASD | no |
| Allosteric Prediction | yes (0.895387611) |
| Ortholog in Animals | Alpaca_ GC ( ortholog_one2one ) Dog_ GC ( ortholog_one2one ) GuineaPig_ GC ( ortholog_one2one ) Macaque_ GC ( ortholog_one2one ) Mouse_ Gc ( ortholog_one2one ) Pig_ GC ( ortholog_one2one ) Rat_ Gc ( ortholog_one2one ) Rabbit_ GC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AFM, AFP, ALB |
| Tissue | liver, gall.bladder |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121909677 rs699664 rs121909675 rs121909681 rs121909682 rs121909676 rs121909679 rs28928872 rs121909678 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10910912}; Multi-pass membrane protein {ECO:0000269|PubMed:10910912}. |
| Mouse PG classification | NA |
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