| Gene Information | |
|---|---|
| Gene Name | PSCA |
| Organism | Homo sapiens (Human) |
| Gene Length | 114 |
| Protein Names | Prostate stem cell antigen |
| Target Name | prostate stem cell antigen |
| Target Type | Clinical trial target |
| Gene Age | 101 ( ENSG00000167653 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43653 |
| Gene Card | PSCA |
| Uniprot ID | O43653 |
| Pfam | PF00021 |
| In ASD | no |
| Allosteric Prediction | no (-0.853067385) |
| Ortholog in Animals | Alpaca_ PSCA ( ortholog_one2one ) Dog_ PSCA ( ortholog_one2one ) GuineaPig_ PSCA ( ortholog_one2one ) Macaque_ PSCA ( ortholog_one2one ) Mouse_ Psca ( ortholog_one2one ) Pig_ PSCA ( ortholog_one2one ) Rat_ Psca ( ortholog_one2one ) Rabbit_ PSCA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPIHBP1, LY6E |
| Tissue | stomach |
| Tissue Specificity | Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients. {ECO:0000269|PubMed:10713670, ECO:0000269|PubMed:18488030, ECO:0000269|PubMed:25680266}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2294008 rs3736001 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9465086}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:9465086}. |
| Mouse PG classification | NA |
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