Gene Information
Gene NamePOLR3A
OrganismHomo sapiens (Human)
Gene Length1390
Protein NamesDNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000148606 )
Evolutionary StageCellular_organisms
AlphaFoldDBO14802
Gene CardPOLR3A
Uniprot IDO14802
PfamPF04997; PF00623; PF04983; PF05000; PF04998
In ASDno
Allosteric Predictionno (-0.126114284)
Ortholog in AnimalsAlpaca_ POLR3A ( ortholog_one2one )
Dog_ POLR3A ( ortholog_one2one )
GuineaPig_ POLR3A ( ortholog_one2one )
Macaque_ POLR3A ( ortholog_one2one )
Mouse_ Polr3a ( ortholog_one2one )
Pig_ POLR3A ( ortholog_one2one )
Rat_ Polr3a ( ortholog_one2one )
Rabbit_ POLR3A ( ortholog_one2one )
OhnologsNA
ParalogsPOLR1A, POLR2A
TissueNA
Tissue SpecificityExpressed in the brain, in the cortex and the white matter (at protein level). {ECO:0000269|PubMed:21855841}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.089819(Rat);0.065673(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7A6H  (EM  3.30A  )  7AE1  (EM  2.80A  )  7AE3  (EM  3.10A  )  7AEA  (EM  3.40A  )  7AST  (EM  4.00A  )  7D58  (EM  2.90A  )  7D59  (EM  3.10A  )  7DN3  (EM  3.50A  )  7DU2  (EM  3.35A  )  7FJI  (EM  3.60A  )  7FJJ  (EM  3.60A  ) 
DBSNP rs1375717376  rs1217230904  rs267608673  rs1307896663  rs267608668  rs34588967  rs762708292  rs267608676  rs267608670  rs35354908  rs267608679  rs267608672  rs267608671  rs267608681  rs1399429058  rs267608682  rs778985686  rs138305578  rs371703979  rs757209071  rs768222183 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11416169}.
Mouse PG classificationNA
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