| Gene Information | |
|---|---|
| Gene Name | GBF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1859 |
| Protein Names | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000107862 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92538 |
| Gene Card | GBF1 |
| Uniprot ID | Q92538 |
| Pfam | PF16213; PF01369; PF12783 |
| In ASD | no |
| Allosteric Prediction | yes (0.410284825) |
| Ortholog in Animals | Alpaca_ GBF1 ( ortholog_one2one ) Dog_ GBF1 ( ortholog_one2one ) GuineaPig_ GBF1 ( ortholog_one2one ) Macaque_ GBF1 ( ortholog_one2one ) Mouse_ Gbf1 ( ortholog_one2one ) Pig_ GBF1 ( ortholog_one2one ) Rat_ Gbf1 ( ortholog_one2one ) Rabbit_ GBF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PSD2, PSD3, ARFGEF2, CYTH4, MON2, ARFGEF1, PSD, PSD4, FBXO8, CYTH1, IQSEC3, IQSEC1, CYTH2, IQSEC2, CYTH3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11191274 |
| Subcellular location [CC] | Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12808027}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23386609}. Golgi apparatus {ECO:0000269|PubMed:31519766}. Cytoplasm {ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:31519766}. Lipid droplet {ECO:0000269|PubMed:21789191}. Membrane; Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes (PubMed:15616190). Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (PubMed:15813748). In neutrophils is translocated from the Golgi to the leading edge upon GPCR stimulation (PubMed:22573891). Localization to lipid droplets is questionable (PubMed:22185782). {ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000305|PubMed:15616190, ECO:0000305|PubMed:15813748}. |
| Mouse PG classification | NA |
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