| Gene Information | |
|---|---|
| Gene Name | GATM |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase) |
| Target Name | glycine amidinotransferase, mitochondrial |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000171766 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P50440 |
| Gene Card | GATM |
| Uniprot ID | P50440 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.27043825) |
| Ortholog in Animals | Alpaca_ GATM ( ortholog_one2one ) Dog_ GATM ( ortholog_one2one ) GuineaPig_ GATM ( ortholog_one2one ) Macaque_ GATM ( ortholog_one2one ) Mouse_ Gatm ( ortholog_one2one ) Pig_ GATM ( ortholog_one2one ) Rat_ Gatm ( ortholog_one2one ) Rabbit_ GATM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. {ECO:0000269|PubMed:16125225, ECO:0000269|PubMed:16614068, ECO:0000269|PubMed:16820567}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1JDW (X-ray 1.90A ) 1JDX (X-ray 2.40A ) 2JDW (X-ray 2.10A ) 2JDX (X-ray 2.90A ) 3JDW (X-ray 2.40A ) 4JDW (X-ray 2.50A ) 5JDW (X-ray 2.60A ) 6JDW (X-ray 2.50A ) 7JDW (X-ray 2.37A ) 8JDW (X-ray 2.30A ) 9JDW (X-ray 2.50A ) |
| DBSNP | rs370155767 rs34991226 rs376335787 rs147804855 rs1288775 rs376982466 rs377578020 rs397514709 rs374059924 rs202225656 rs146057680 rs371447931 rs1889443535 rs373802463 rs1889422661 rs142814307 rs1461653218 rs1244824806 rs374592247 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Probably attached to the outer side of the inner membrane.; [Isoform 2]: Cytoplasm. |
| Mouse PG classification | LPG |
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