| Gene Information | |
|---|---|
| Gene Name | CYP4F2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000186115 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P78329 |
| Gene Card | CYP4F2 |
| Uniprot ID | P78329 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.725211109) |
| Ortholog in Animals | Alpaca_ CYP4F2 ( ortholog_one2one ) Dog_ CYP4F22 ( ortholog_one2one ) Mouse_ Cyp4f14 ( ortholog_one2many ) Mouse_ Cyp4f40 ( ortholog_one2many ) Mouse_ Cyp4f15 ( ortholog_one2many ) Rat_ Cyp4f40 ( ortholog_one2many ) Rat_ Cyp4f4 ( ortholog_one2many ) Rat_ Cyp4f1 ( ortholog_one2many ) Rabbit_ CYP4F2 ( ortholog_one2one ) |
| Ohnologs | CYP4B1, CYP4A22, CYP4X1, CYP4A11 |
| Paralogs | CYP4F12, CYP4A22, CYP4A11, CYP4B1, CYP4F8, CYP4F11, CYP19A1, CYP4F22, CYP4X1, CYP4Z1, CYP4F3, CYP4V2 |
| Tissue | duodenum, kidney, liver, small.intestine, brain, epididymis |
| Tissue Specificity | Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3093104 rs3093105 rs3093153 rs1599353639 rs2108622 rs3093200 |
| Subcellular location [CC] | Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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