| Gene Information | |
|---|---|
| Gene Name | GAS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141013 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95995 |
| Gene Card | GAS8 |
| Uniprot ID | O95995 |
| Pfam | PF13851 |
| In ASD | no |
| Allosteric Prediction | no (-1.595236775) |
| Ortholog in Animals | Alpaca_ GAS8 ( ortholog_one2one ) GuineaPig_ GAS8 ( ortholog_one2one ) Macaque_ GAS8 ( ortholog_one2one ) Mouse_ Gas8 ( ortholog_one2one ) Pig_ GAS8 ( ortholog_one2one ) Rat_ Gas8 ( ortholog_one2one ) Rabbit_ GAS8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751). {ECO:0000269|PubMed:26387594, ECO:0000269|PubMed:27120127, ECO:0000269|PubMed:9790751}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs868044 rs17178299 rs147993982 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10969087}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:16643277, ECO:0000269|PubMed:26387594}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q60779}. Golgi apparatus {ECO:0000269|PubMed:16643277}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q7XJ96}. Note=Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q60779, ECO:0000269|PubMed:10969087}. |
| Mouse PG classification | NA |
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