| Gene Information | |
|---|---|
| Gene Name | GAS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 678 |
| Protein Names | Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) |
| Target Name | axl receptor tyrosine kinase ligand |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000183087 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14393 |
| Gene Card | GAS6 |
| Uniprot ID | Q14393 |
| Pfam | PF12662; PF07645; PF00594; PF00054; PF02210 |
| In ASD | no |
| Allosteric Prediction | yes (0.9469034) |
| Ortholog in Animals | Dog_ GAS6 ( ortholog_one2one ) GuineaPig_ GAS6 ( ortholog_one2one ) Macaque_ GAS6 ( ortholog_one2one ) Mouse_ Gas6 ( ortholog_one2one ) Pig_ GAS6 ( ortholog_one2one ) Rat_ Gas6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MEGF11, MEGF10, MEGF6 |
| Tissue | NA |
| Tissue Specificity | Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H30 (X-ray 2.20A ) 2C5D (X-ray 3.30A ) 4RA0 (X-ray 3.07A ) 5VXZ (X-ray 2.30A ) |
| DBSNP | rs201378406 rs146159446 rs144457857 rs7992146 rs79807310 rs73583241 rs199700915 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:9326369}. |
| Mouse PG classification | NA |
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