| Gene Information | |
|---|---|
| Gene Name | GAS2L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 880 |
| Protein Names | GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000270765 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NHY3 |
| Gene Card | GAS2L2 |
| Uniprot ID | Q8NHY3 |
| Pfam | PF00307; PF02187 |
| In ASD | no |
| Allosteric Prediction | no (-1.650809681) |
| Ortholog in Animals | Alpaca_ GAS2L2 ( ortholog_one2one ) Dog_ GAS2L2 ( ortholog_one2one ) Macaque_ GAS2L2 ( ortholog_one2one ) Mouse_ Gas2l2 ( ortholog_one2one ) Pig_ GAS2L2 ( ortholog_one2one ) Rat_ Gas2l2 ( ortholog_one2one ) Rabbit_ GAS2L2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4 |
| Tissue | NA |
| Tissue Specificity | Expressed in bronchial and nasal epithelial cells (at protein level) (PubMed:30665704). Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (PubMed:12584248, PubMed:30665704). Expressed at low levels in stomach and colon (PubMed:30665704). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:30665704}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11654604 rs12602590 rs3744374 rs56386706 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:30665704}. Cell membrane {ECO:0000250|UniProtKB:Q5SSG4}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30665704}. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (PubMed:24706950). {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000269|PubMed:24706950}. |
| Mouse PG classification | NA |
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