| Gene Information | |
|---|---|
| Gene Name | GAS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Growth arrest-specific protein 2 (GAS-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000148935 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43903 |
| Gene Card | GAS2 |
| Uniprot ID | O43903 |
| Pfam | PF00307; PF02187 |
| In ASD | no |
| Allosteric Prediction | no (-1.223101913) |
| Ortholog in Animals | Alpaca_ GAS2 ( ortholog_one2one ) Dog_ GAS2 ( ortholog_one2one ) GuineaPig_ GAS2 ( ortholog_one2one ) Macaque_ GAS2 ( ortholog_one2one ) Mouse_ Gas2 ( ortholog_one2one ) Pig_ GAS2 ( ortholog_one2one ) Rat_ Gas2 ( ortholog_one2one ) Rabbit_ GAS2 ( ortholog_one2one ) |
| Ohnologs | GAS2L3, GAS2L1 |
| Paralogs | ASPM, MICALL2, EHBP1L1, SMTNL1, EHBP1, MICALL1, GAS2L1 |
| Tissue | liver |
| Tissue Specificity | Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950}. Membrane {ECO:0000250|UniProtKB:P11862}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11862}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles. {ECO:0000250|UniProtKB:P11862}. |
| Mouse PG classification | NA |
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