| Gene Information | |
|---|---|
| Gene Name | TYRP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 537 |
| Protein Names | 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1) |
| Target Name | melanoma antigen gp75 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000107165 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17643 |
| Gene Card | TYRP1 |
| Uniprot ID | P17643 |
| Pfam | PF00264 |
| In ASD | no |
| Allosteric Prediction | no (-0.642970265) |
| Ortholog in Animals | Alpaca_ TYRP1 ( ortholog_one2one ) Dog_ TYRP1 ( ortholog_one2one ) GuineaPig_ TYRP1 ( ortholog_one2one ) Macaque_ TYRP1 ( ortholog_one2one ) Mouse_ Tyrp1 ( ortholog_one2one ) Pig_ TYRP1 ( ortholog_one2one ) Rat_ Tyrp1 ( ortholog_one2one ) Rabbit_ TYRP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TYR, DCT |
| Tissue | skin, heart, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Pigment cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.350650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5M8L (X-ray 2.35A ) 5M8M (X-ray 2.65A ) 5M8N (X-ray 2.60A ) 5M8O (X-ray 2.50A ) 5M8P (X-ray 2.80A ) 5M8Q (X-ray 2.85A ) 5M8R (X-ray 2.40A ) 5M8S (X-ray 2.20A ) 5M8T (X-ray 2.35A ) |
| DBSNP | rs61758405 rs387907171 rs16929374 rs281865424 |
| Subcellular location [CC] | Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P07147}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |