| Gene Information | |
|---|---|
| Gene Name | ASIC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 528 |
| Protein Names | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2) |
| Target Name | acid-sensing ion channel 1 |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000110881 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P78348 |
| Gene Card | ASIC1 |
| Uniprot ID | P78348 |
| Pfam | PF00858 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000089318) |
| Ortholog in Animals | Alpaca_ ASIC1 ( ortholog_one2one ) Dog_ ASIC1 ( ortholog_one2one ) GuineaPig_ ASIC1 ( ortholog_one2one ) Macaque_ ASIC1 ( ortholog_one2one ) Mouse_ Asic1 ( ortholog_one2one ) Pig_ ASIC1 ( ortholog_one2one ) Rat_ Asic1 ( ortholog_one2one ) Rabbit_ ASIC1 ( ortholog_one2one ) |
| Ohnologs | ASIC2, ASIC4, ASIC3 |
| Paralogs | ASIC5, SCNN1B, SCNN1G, ASIC4, SCNN1A, SCNN1D, ASIC2, ASIC3 |
| Tissue | brain |
| Tissue Specificity | Expressed in most or all neurons. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6L6I (X-ray 3.24A ) 6L6N (X-ray 2.86A ) 7CFS (EM 3.56A ) 7CFT (EM 3.90A ) 7RNN (EM 2.86A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi-pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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