| Gene Information | |
|---|---|
| Gene Name | GAQ |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P50148 |
| Gene Card | GNAQ |
| Uniprot ID | P50148 |
| Pfam | PF00503 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level). {ECO:0000269|PubMed:21923740, ECO:0000269|PubMed:8664309}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);0.023077(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6VU5 (EM 3.50A ) 7EZM (EM 2.90A ) 7F6H (EM 2.90A ) 7F6I (EM 2.80A ) 7F8W (EM 3.10A ) 7XOW (EM 3.10A ) 7XOX (EM 3.10A ) |
| DBSNP | rs397514698 rs121913492 rs1059531 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19001095}; Lipid-anchor {ECO:0000269|PubMed:19001095}. Golgi apparatus {ECO:0000269|PubMed:19001095}. Nucleus {ECO:0000250|UniProtKB:P21279}. Nucleus membrane {ECO:0000250|UniProtKB:P21279}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:P21279}. |
| Mouse PG classification | NA |
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