| Gene Information | |
|---|---|
| Gene Name | HLA-6.2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 358 |
| Protein Names | HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P13747 |
| Gene Card | HLA-E |
| Uniprot ID | P13747 |
| Pfam | PF07654; PF00129; PF06623 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level). {ECO:0000269|PubMed:17179229}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1KPR (X-ray 2.80A ) 1KTL (X-ray 3.10A ) 1MHE (X-ray 2.85A ) 2ESV (X-ray 2.60A ) 3AM8 (X-ray 2.80A ) 3BZE (X-ray 2.50A ) 3BZF (X-ray 2.50A ) 3CDG (X-ray 3.40A ) 3CII (X-ray 4.41A ) 5W1V (X-ray 3.31A ) 5W1W (X-ray 3.10A ) 6GGM (X-ray 2.73A ) 6GH1 (X-ray 2.10A ) 6GH4 (X-ray 2.16A ) 6GHN (X-ray 2.54A ) 6GL1 (X-ray 2.62A ) 6ZKW (X-ray 2.26A ) 6ZKX (X-ray 2.17A ) 6ZKY (X-ray 2.65A ) 6ZKZ (X-ray 2.30A ) 7BH8 (X-ray 1.80A ) 7NDQ (X-ray 2.55A ) 7NDT (X-ray 3.00A ) 7NDU (X-ray 2.90A ) 7P49 (X-ray 2.05A ) 7P4B (X-ray 1.72A ) |
| DBSNP | rs1059510 rs1264457 rs41562314 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:9427624}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000269|PubMed:17179229}.; [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted {ECO:0000269|PubMed:17179229}. |
| Mouse PG classification | NA |
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