| Gene Information | |
|---|---|
| Gene Name | GAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1047 |
| Protein Names | Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P20936 |
| Gene Card | RASA1 |
| Uniprot ID | P20936 |
| Pfam | PF00168; PF00169; PF00616; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). {ECO:0000269|PubMed:8360177}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002061(Rat);0.116761(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WER (X-ray 1.60A ) 1WQ1 (X-ray 2.50A ) 2GQI (NMR - ) 2GSB (NMR - ) 2J05 (X-ray 1.50A ) 2J06 (X-ray 1.80A ) 2M51 (NMR - ) 4FSS (X-ray 2.25A ) 6PXB (X-ray 1.75A ) 6PXC (X-ray 1.60A ) 6WAX (X-ray 1.50A ) 6WAY (X-ray 1.50A ) |
| DBSNP | rs137853214 rs137853215 rs137853216 rs145752649 rs137853217 rs745690594 rs373098580 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:8360177}. |
| Mouse PG classification | NA |
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