Gene Information
Gene NameMMP1
OrganismHomo sapiens (Human)
Gene Length469
Protein NamesInterstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Target Namematrix metalloproteinase-1
Target TypeSuccessful target
Gene Age645 ( ENSG00000196611 )
Evolutionary StageVertebrata
AlphaFoldDBP03956
Gene CardMMP1
Uniprot IDP03956
PfamPF00045; PF00413; PF01471
In ASDno
Allosteric Predictionyes (0.953936875)
Ortholog in AnimalsAlpaca_ MMP1 ( ortholog_one2one )
Dog_ MMP1 ( ortholog_one2one )
GuineaPig_ MMP1 ( ortholog_one2one )
Macaque_ MMP1 ( ortholog_one2one )
Mouse_ Mmp1a ( ortholog_one2many )
Mouse_ Mmp1b ( ortholog_one2many )
Pig_ MMP1 ( ortholog_one2one )
Rat_ Mmp1 ( ortholog_one2many )
Rat_ Mmp1b ( ortholog_one2many )
Rabbit_ MMP1 ( ortholog_one2one )
OhnologsMMP25, MMP2, MMP11, MMP15, MMP17, MMP16
ParalogsMMP24, MMP16, MMP21, MMP14, MMP2, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11
Tissuegall.bladder, urinary.bladder
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AYK  (NMR  -  )  1CGE  (X-ray  1.90A  )  1CGF  (X-ray  2.10A  )  1CGL  (X-ray  2.40A  )  1HFC  (X-ray  1.50A  )  1SU3  (X-ray  2.20A  )  2AYK  (NMR  -  )  2CLT  (X-ray  2.67A  )  2J0T  (X-ray  2.54A  )  2TCL  (X-ray  2.20A  )  3AYK  (NMR  -  )  3SHI  (X-ray  2.20A  )  4AUO  (X-ray  3.00A  )  4AYK  (NMR  -  )  966C  (X-ray  1.90A  ) 
DBSNP rs554499  rs17879973  rs513964  rs12282811  rs17879165  rs17884120 
Subcellular location [CC]Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}.
Mouse PG classificationNA
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