| Gene Information | |
|---|---|
| Gene Name | AP2M1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000161203 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96CW1 |
| Gene Card | AP2M1 |
| Uniprot ID | Q96CW1 |
| Pfam | PF00928; PF01217 |
| In ASD | no |
| Allosteric Prediction | yes (0.81108662) |
| Ortholog in Animals | Alpaca_ AP2M1 ( ortholog_one2one ) Dog_ AP2M1 ( ortholog_one2one ) GuineaPig_ AP2M1 ( ortholog_one2one ) Macaque_ AP2M1 ( ortholog_one2one ) Mouse_ Ap2m1 ( ortholog_one2one ) Pig_ AP2M1 ( ortholog_one2one ) Rat_ Ap2m1 ( ortholog_one2one ) Rabbit_ AP2M1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AP3M1, STON2, AP3M2, AP4M1, AP1M1, STON1, AP1M2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.029508(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1H6E (X-ray 3.60A ) 6BNT (X-ray 3.20A ) 6URI (X-ray 3.00A ) |
| DBSNP | rs1577059692 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31104773}. Membrane, coated pit {ECO:0000269|PubMed:31104773}; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P84091}. |
| Mouse PG classification | NA |
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