| Gene Information | |
|---|---|
| Gene Name | SLC41A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Solute carrier family 41 member 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000133065 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q8IVJ1 |
| Gene Card | SLC41A1 |
| Uniprot ID | Q8IVJ1 |
| Pfam | PF01769 |
| In ASD | no |
| Allosteric Prediction | no (-0.462606324) |
| Ortholog in Animals | Alpaca_ SLC41A1 ( ortholog_one2many ) Dog_ SLC41A1 ( ortholog_one2one ) GuineaPig_ SLC41A1 ( ortholog_one2one ) Macaque_ SLC41A1 ( ortholog_one2one ) Mouse_ Slc41a1 ( ortholog_one2one ) Pig_ SLC41A1 ( ortholog_one2one ) Rat_ Slc41a1 ( ortholog_one2one ) Rabbit_ SLC41A1 ( ortholog_one2one ) |
| Ohnologs | SLC41A3, SLC41A2 |
| Paralogs | SLC41A2, SLC41A3 |
| Tissue | NA |
| Tissue Specificity | Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. In the kidney, it is expressed in the distal convoluted tubules, macula densa, and thick ascending limb tubular segments of the nephrons (PubMed:23661805). {ECO:0000269|PubMed:12810078, ECO:0000269|PubMed:23661805}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1305279636 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:23976986}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23661805}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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