| Gene Information | |
|---|---|
| Gene Name | GALNT12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 581 |
| Protein Names | Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000119514 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IXK2 |
| Gene Card | GALNT12 |
| Uniprot ID | Q8IXK2 |
| Pfam | PF00535; PF00652 |
| In ASD | no |
| Allosteric Prediction | no (-0.726050683) |
| Ortholog in Animals | Alpaca_ GALNT12 ( ortholog_one2one ) Dog_ GALNT12 ( ortholog_one2one ) GuineaPig_ GALNT12 ( ortholog_one2one ) Macaque_ GALNT12 ( ortholog_one2one ) Mouse_ Galnt12 ( ortholog_one2one ) Pig_ GALNT12 ( ortholog_one2one ) Rat_ Galnt12 ( ortholog_one2one ) Rabbit_ GALNT12 ( ortholog_one2one ) |
| Ohnologs | GALNT6, GALNT3 |
| Paralogs | GALNT11, GALNT10, GALNTL6, GALNT1, GALNT16, GALNTL5, GALNT18, GALNT2, GALNT13, GALNT9, GALNT14, GALNT17, GALNT7, GALNT6, GALNT8, GALNT5, GALNT3, GALNT15, GALNT4 |
| Tissue | colon, epididymis, gall.bladder, lung, pancreas, parotid.gland, pineal.gland, smooth.muscle |
| Tissue Specificity | Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate. {ECO:0000269|PubMed:12135769}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6PXU (X-ray 2.01A ) |
| DBSNP | rs1356894484 rs10987768 rs1137654 rs41306504 rs367645298 rs149726976 rs145236923 rs920049418 rs868590153 rs1272530441 rs267606840 rs1285871027 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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