Gene Information
Gene NameGALNS
OrganismHomo sapiens (Human)
Gene Length522
Protein NamesN-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)
Target Namen-acetylgalactosamine 6 sulfatase
Target TypeSuccessful target
Gene Age987 ( ENSG00000141012 )
Evolutionary StageEuk+Bac
AlphaFoldDBP34059
Gene CardGALNS
Uniprot IDP34059
PfamPF00884
In ASDno
Allosteric Predictionno (-0.011099796)
Ortholog in AnimalsAlpaca_ GALNS ( ortholog_one2one )
Dog_ GALNS ( ortholog_one2one )
GuineaPig_ GALNS ( ortholog_one2one )
Macaque_ GALNS ( ortholog_one2one )
Mouse_ Galns ( ortholog_one2one )
Pig_ GALNS ( ortholog_one2one )
Rat_ Galns ( ortholog_one2one )
Rabbit_ GALNS ( ortholog_one2one )
OhnologsARSD, ARSF, STS, ARSL, ARSH
ParalogsIDS, ARSA, ARSL, SULF1, STS, ARSI, ARSG, ARSH, SGSH, SULF2, GNS, ARSB, ARSJ, ARSF, ARSD, ARSK
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4FDI  (X-ray  2.20A  4FDJ  (X-ray  2.81A 
DBSNP rs866745731  rs794729202  rs755832705  rs1283377907  rs199638097  rs191519947  rs1296755011  rs1421990673  rs118204447  rs145798311  rs11862754  rs118204445  rs1263679818  rs1209154325  rs141340188  rs1028668536  rs118204441  rs118204441  rs763184657  rs118204438  rs1444754604  rs746949976  rs118204436  rs146093755  rs794727625  rs577334837  rs1168278189  rs559063128  rs398123438  rs1301146300  rs1308500116  rs118204444  rs761725425  rs768757999  rs1301198698  rs148565559  rs775732598  rs7187889  rs772413313  rs118204435  rs771810111  rs747805226  rs34745339  rs753051547  rs398123440  rs761385192  rs1199639828  rs775300515  rs773283163  rs118204442  rs144067930  rs768664270  rs770053354  rs975409254  rs118204448  rs149239881  rs118204443  rs377285422  rs118204446  rs746756997  rs1269110043  rs267606838  rs761386453  rs769748679  rs778120439  rs150734270  rs770908172  rs200763834  rs118204437  rs1221167717  rs373739301  rs398123429  rs398123430  rs2303269  rs749578474  rs142822371  rs398123432  rs114703967  rs1204485789  rs118204440  rs78127134  rs760300454  rs1401175486  rs886039377  rs1303492021  rs398123433 
Subcellular location [CC]Lysosome.
Mouse PG classificationNA
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