| Gene Information | |
|---|---|
| Gene Name | MED1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1581 |
| Protein Names | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) |
| Target Name | mediator of rna polymerase ii transcription subunit 1 |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000125686 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15648 |
| Gene Card | MED1 |
| Uniprot ID | Q15648 |
| Pfam | PF10744 |
| In ASD | no |
| Allosteric Prediction | yes (0.372661318) |
| Ortholog in Animals | Alpaca_ MED1 ( ortholog_one2one ) Dog_ MED1 ( ortholog_one2one ) GuineaPig_ MED1 ( ortholog_one2one ) Macaque_ MED1 ( ortholog_one2one ) Mouse_ Med1 ( ortholog_one2one ) Pig_ MED1 ( ortholog_one2one ) Rat_ Med1 ( ortholog_one2one ) Rabbit_ MED1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:9444950, ECO:0000269|PubMed:9653119}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.134827(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1RJK (X-ray 1.99A ) 1RK3 (X-ray 2.20A ) 1RKG (X-ray 1.90A ) 1RKH (X-ray 2.28A ) 2O4J (X-ray 1.74A ) 2O4R (X-ray 1.98A ) 2ZFX (X-ray 1.99A ) 3A2H (X-ray 2.50A ) 3AUN (X-ray 1.81A ) 3VJS (X-ray 1.93A ) 3VJT (X-ray 2.00A ) 3VRT (X-ray 2.40A ) 3VRU (X-ray 2.00A ) 3VRV (X-ray 1.90A ) 3VRW (X-ray 2.40A ) 3W0G (X-ray 1.94A ) 3W0H (X-ray 1.80A ) 3W0I (X-ray 1.90A ) 3W0J (X-ray 1.84A ) 3W5P (X-ray 1.90A ) 3W5Q (X-ray 1.90A ) 3W5R (X-ray 2.20A ) 3W5T (X-ray 2.29A ) 3WT5 (X-ray 1.90A ) 3WT6 (X-ray 2.00A ) 3WT7 (X-ray 2.40A ) 3WTQ (X-ray 2.10A ) 4YNK (X-ray 2.30A ) 5AWJ (X-ray 2.20A ) 5AWK (X-ray 2.90A ) 5B41 (X-ray 1.89A ) 5B5B (X-ray 2.00A ) 5GIC (X-ray 2.35A ) 5GID (X-ray 2.15A ) 5GIE (X-ray 2.39A ) 5XPM (X-ray 2.20A ) 5XPN (X-ray 1.96A ) 5XPO (X-ray 2.28A ) 5XPP (X-ray 2.85A ) 5XUQ (X-ray 2.80A ) 5XZF (X-ray 2.10A ) 5XZH (X-ray 2.00A ) 5ZWE (X-ray 2.72A ) 5ZWF (X-ray 2.10A ) 5ZWH (X-ray 2.38A ) 5ZWI (X-ray 2.40A ) 6D94 (X-ray 1.90A ) 6JEZ (X-ray 2.30A ) 6K5O (X-ray 1.80A ) 6ONJ (X-ray 2.30A ) 7C7V (X-ray 2.00A ) 7C7W (X-ray 1.90A ) 7EMF (EM 3.50A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7ENJ (EM 4.40A ) 7OXU (X-ray 2.39A ) 7VQP (X-ray 1.94A ) |
| DBSNP | rs1139825 rs35668211 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:16574658}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. |
| Mouse PG classification | NA |
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