| Gene Information | |
|---|---|
| Gene Name | CRIM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1036 |
| Protein Names | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000150938 ) 3 ( ENSG00000277354 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NZV1 |
| Gene Card | CRIM1 |
| Uniprot ID | Q9NZV1 |
| Pfam | PF02822; PF19442; PF00219; PF00093 |
| In ASD | no |
| Allosteric Prediction | no (-0.457942623) |
| Ortholog in Animals | Alpaca_ CRIM1 ( ortholog_one2one ) Dog_ CRIM1 ( ortholog_one2one ) GuineaPig_ CRIM1 ( ortholog_one2one ) Macaque_ CRIM1 ( ortholog_one2one ) Mouse_ Crim1 ( ortholog_one2one ) Pig_ CRIM1 ( ortholog_one2one ) Rat_ Crim1 ( ortholog_one2one ) Rabbit_ CRIM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHRDL1, MUC5B, KCP, CHRDL2, CHRD, VWF, VWCE, OTOGL, MUC6, MUC5AC, OTOG, ZAN, BMPER, TECTA, FCGBP, MUC2, MUC19, VWC2L, VWC2 |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). {ECO:0000269|PubMed:10642437, ECO:0000269|PubMed:12464430}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12997487 rs59929305 |
| Subcellular location [CC] | [Processed cysteine-rich motor neuron 1 protein]: Secreted.; Cell membrane {ECO:0000269|PubMed:12805376}; Single-pass type I membrane protein {ECO:0000269|PubMed:12805376}. |
| Mouse PG classification | NA |
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