| Gene Information | |
|---|---|
| Gene Name | ATP2A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 999 |
| Protein Names | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000074370 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q93084 |
| Gene Card | ATP2A3 |
| Uniprot ID | Q93084 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.297811396) |
| Ortholog in Animals | Alpaca_ ATP2A3 ( ortholog_one2one ) Dog_ ATP2A3 ( ortholog_one2one ) GuineaPig_ ATP2A3 ( ortholog_one2one ) Macaque_ ATP2A3 ( ortholog_one2one ) Mouse_ Atp2a3 ( ortholog_one2one ) Pig_ ATP2A3 ( ortholog_one2one ) Rat_ Atp2a3 ( ortholog_one2one ) Rabbit_ ATP2A3 ( ortholog_one2one ) |
| Ohnologs | ATP2A2, ATP2A1 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | NA |
| Tissue Specificity | Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs144535413 rs11654827 |
| Subcellular location [CC] | Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. |
| Mouse PG classification | NA |
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