Gene Information
Gene NameGSDMC
OrganismHomo sapiens (Human)
Gene Length508
Protein NamesGasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)]
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000147697 )
3 ( ENSG00000285114 )
Evolutionary StageVertebrata
AlphaFoldDBQ9BYG8
Gene CardGSDMC
Uniprot IDQ9BYG8
PfamPF04598; PF17708
In ASDno
Allosteric Predictionno (-1.753990219)
Ortholog in AnimalsAlpaca_ GSDMC ( ortholog_one2one )
Macaque_ GSDMC ( ortholog_one2one )
Mouse_ Gsdmc ( ortholog_one2many )
Mouse_ Gsdmc3 ( ortholog_one2many )
Mouse_ Gsdmc4 ( ortholog_one2many )
Mouse_ Gsdmc2 ( ortholog_one2many )
Rat_ Gsdmc ( ortholog_one2one )
OhnologsNA
ParalogsGSDMA, GSDMD, GSDMB, PJVK
Tissueskin, esophagus, spleen, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina
Tissue SpecificityExpressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310). {ECO:0000269|PubMed:11223543, ECO:0000269|PubMed:19051310}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs10090835  rs16904151  rs4144738 
Subcellular location [CC][Gasdermin-C]: Cytoplasm, cytosol {ECO:0000269|PubMed:11223543}.;
[Gasdermin-C, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Mouse PG classificationNA
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