| Gene Information | |
|---|---|
| Gene Name | GAK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1311 |
| Protein Names | Cyclin-G-associated kinase (EC 2.7.11.1) |
| Target Name | cyclin-g-associated kinase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000178950 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14976 |
| Gene Card | GAK |
| Uniprot ID | O14976 |
| Pfam | PF00069; PF10409 |
| In ASD | no |
| Allosteric Prediction | yes (0.11869926) |
| Ortholog in Animals | Alpaca_ GAK ( ortholog_one2one ) Dog_ GAK ( ortholog_one2one ) GuineaPig_ GAK ( ortholog_one2one ) Macaque_ GAK ( ortholog_one2one ) Mouse_ Gak ( ortholog_one2one ) Pig_ GAK ( ortholog_one2one ) Rat_ Gak ( ortholog_one2one ) Rabbit_ GAK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DNAJC6 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highest in testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002051(Rat);0.04966(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4C57 (X-ray 2.55A ) 4C58 (X-ray 2.16A ) 4C59 (X-ray 2.80A ) 4O38 (X-ray 2.10A ) 4Y8D (X-ray 2.10A ) 5Y7Z (X-ray 2.80A ) 5Y80 (X-ray 2.50A ) |
| DBSNP | rs768962219 rs34255232 rs34585705 rs149842313 rs773153935 rs35227944 rs55801437 rs56169884 rs56326341 rs2306242 rs1134921 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:10625686}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10625686}. Cell junction, focal adhesion {ECO:0000305|PubMed:10625686}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions. |
| Mouse PG classification | NA |
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