| Gene Information | |
|---|---|
| Gene Name | SLC6A20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000163817 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NP91 |
| Gene Card | SLC6A20 |
| Uniprot ID | Q9NP91 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | no (-0.763024407) |
| Ortholog in Animals | Alpaca_ SLC6A20 ( ortholog_one2one ) Dog_ SLC6A20 ( ortholog_one2one ) Macaque_ SLC6A20 ( ortholog_one2one ) Mouse_ Slc6a20b ( ortholog_one2many ) Mouse_ Slc6a20a ( ortholog_one2many ) Pig_ SLC6A20 ( ortholog_one2one ) Rat_ Slc6a20 ( ortholog_one2many ) Rat_ RGD1566368 ( ortholog_one2many ) Rabbit_ SLC6A20 ( ortholog_one2one ) |
| Ohnologs | SLC6A15, SLC6A19 |
| Paralogs | SLC6A9, SLC6A2, SLC6A18, SLC6A7, SLC6A4, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12, SLC6A3 |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. Expressed in neurons (PubMed:33428810). {ECO:0000269|PubMed:19033659, ECO:0000269|PubMed:33428810, ECO:0000269|PubMed:9932288}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2271615 rs17279437 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250|UniProtKB:Q8VDB9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VDB9}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000250|UniProtKB:Q8VDB9}. |
| Mouse PG classification | NA |
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