| Gene Information | |
|---|---|
| Gene Name | KISS1R |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor) |
| Target Name | kiss-1 receptor |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000116014 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q969F8 |
| Gene Card | KISS1R |
| Uniprot ID | Q969F8 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000290784) |
| Ortholog in Animals | Alpaca_ KISS1R ( ortholog_one2one ) Macaque_ KISS1R ( ortholog_one2one ) Mouse_ Kiss1r ( ortholog_one2one ) Pig_ KISS1R ( ortholog_one2one ) Rat_ Kiss1r ( ortholog_one2one ) |
| Ohnologs | GALR1 |
| Paralogs | UTS2R, SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRM1, OPRK1, PTGDR2, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:11387329, ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs104894703 rs28939719 rs73507527 rs397514699 rs745580229 rs144670595 rs350132 rs121908499 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |