| Gene Information | |
|---|---|
| Gene Name | NOTCH4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2003 |
| Protein Names | Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain] |
| Target Name | notch-4 receptor |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000204301 ) 3 ( ENSG00000206312 ) 3 ( ENSG00000223355 ) 3 ( ENSG00000232339 ) 3 ( ENSG00000234876 ) 3 ( ENSG00000235396 ) 3 ( ENSG00000238196 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99466 |
| Gene Card | NOTCH4 |
| Uniprot ID | Q99466 |
| Pfam | PF12796; PF13637; PF00008; PF07645; PF12661; PF06816; PF07684; PF00066 |
| In ASD | no |
| Allosteric Prediction | no (-0.305941262) |
| Ortholog in Animals | Alpaca_ NOTCH4 ( ortholog_one2one ) Macaque_ NOTCH4 ( ortholog_one2one ) Pig_ NOTCH4 ( ortholog_one2one ) Rat_ Notch4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | JAG1, DNER, DLL4, JAG2, DLL1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7OR3 (X-ray 1.80A ) 7OR5 (X-ray 1.80A ) 7OR7 (X-ray 1.80A ) |
| DBSNP | rs915894 rs2071282 rs2071282 rs8192585 rs520692 rs520803 rs422951 rs8192591 rs3132961 rs2022060 rs17604492 rs8192573 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |