Gene Information
Gene NameGADD45GIP1
OrganismHomo sapiens (Human)
Gene Length222
Protein NamesGrowth arrest and DNA damage-inducible proteins-interacting protein 1 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Mitochondrial large ribosomal subunit protein mL64) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000179271 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8TAE8
Gene CardGADD45GIP1
Uniprot IDQ8TAE8
PfamPF10147
In ASDno
Allosteric Predictionno (-0.887961072)
Ortholog in AnimalsAlpaca_ GADD45GIP1 ( ortholog_one2one )
Dog_ GADD45GIP1 ( ortholog_one2one )
GuineaPig_ GADD45GIP1 ( ortholog_one2one )
Macaque_ GADD45GIP1 ( ortholog_one2one )
Mouse_ Gadd45gip1 ( ortholog_one2one )
Pig_ GADD45GIP1 ( ortholog_one2one )
Rat_ Gadd45gip1 ( ortholog_one2one )
Rabbit_ GADD45GIP1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. {ECO:0000269|PubMed:12716909}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.174299(Rat);0.168337(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3J7Y  (EM  3.40A  3J9M  (EM  3.50A  5OOL  (EM  3.06A  5OOM  (EM  3.03A  6I9R  (EM  3.90A  6NU2  (EM  3.90A  6NU3  (EM  4.40A  6VLZ  (EM  2.97A  6VMI  (EM  2.96A  6ZM5  (EM  2.89A  6ZM6  (EM  2.59A  6ZS9  (EM  4.00A  6ZSA  (EM  4.00A  6ZSB  (EM  4.50A  6ZSC  (EM  3.50A  6ZSD  (EM  3.70A  6ZSE  (EM  5.00A  6ZSG  (EM  4.00A  7A5F  (EM  4.40A  7A5G  (EM  4.33A  7A5H  (EM  3.30A  7A5I  (EM  3.70A  7A5J  (EM  3.10A  7A5K  (EM  3.70A  7L08  (EM  3.49A  7L20  (EM  3.15A  7O9K  (EM  3.10A  7O9M  (EM  2.50A  7ODR  (EM  2.90A  7ODS  (EM  3.10A  7ODT  (EM  3.10A  7OF0  (EM  2.20A  7OF2  (EM  2.70A  7OF3  (EM  2.70A  7OF4  (EM  2.70A  7OF5  (EM  2.90A  7OF6  (EM  2.60A  7OF7  (EM  2.50A  7OG4  (EM  3.80A  7OI6  (EM  5.70A  7OI7  (EM  3.50A  7OI8  (EM  3.50A  7OI9  (EM  3.30A  7OIA  (EM  3.20A  7OIB  (EM  3.30A  7OIC  (EM  3.10A  7OID  (EM  3.70A  7OIE  (EM  3.50A  7PD3  (EM  3.40A  7PO4  (EM  2.56A  7QH6  (EM  3.08A  7QH7  (EM  2.89A  7QI4  (EM  2.21A 
DBSNP NA 
Subcellular location [CC]Mitochondrion {ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. Nucleus {ECO:0000269|PubMed:12482659}. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}.
Mouse PG classificationNA
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