| Gene Information | |
|---|---|
| Gene Name | ROR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 937 |
| Protein Names | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) |
| Target Name | neurotrophic tyrosine kinase ror1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000185483 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q01973 |
| Gene Card | ROR1 |
| Uniprot ID | Q01973 |
| Pfam | PF01392; PF07679; PF00051; PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.368120595) |
| Ortholog in Animals | Alpaca_ ROR1 ( ortholog_one2one ) Dog_ ROR1 ( ortholog_one2one ) GuineaPig_ ROR1 ( ortholog_one2one ) Macaque_ ROR1 ( ortholog_one2one ) Mouse_ Ror1 ( ortholog_one2one ) Pig_ ROR1 ( ortholog_one2one ) Rat_ Ror1 ( ortholog_one2one ) Rabbit_ ROR1 ( ortholog_one2one ) |
| Ohnologs | ROR2 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET, ROR2 |
| Tissue | NA |
| Tissue Specificity | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Z55 (NMR - ) 6BA5 (X-ray 1.62A ) 6BAN (X-ray 1.95A ) 6TU9 (X-ray 1.94A ) 7TNG (X-ray 1.40A ) |
| DBSNP | rs7527017 rs760789417 rs55832740 rs34109134 rs1553163562 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:27162350}; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139}. |
| Mouse PG classification | NA |
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