| Gene Information | |
|---|---|
| Gene Name | GABRG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) |
| Target Name | gaba(a) receptor gamma-2 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000113327 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P18507 |
| Gene Card | GABRG2 |
| Uniprot ID | P18507 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.210684621) |
| Ortholog in Animals | Alpaca_ GABRG2 ( ortholog_one2one ) Dog_ GABRG2 ( ortholog_one2one ) GuineaPig_ GABRG2 ( ortholog_one2one ) Macaque_ GABRG2 ( ortholog_one2one ) Mouse_ Gabrg2 ( ortholog_one2one ) Pig_ GABRG2 ( ortholog_one2one ) Rat_ Gabrg2 ( ortholog_one2one ) Rabbit_ GABRG2 ( ortholog_one2one ) |
| Ohnologs | GABRE, GABRG3, GABRA5, GABRA4, GABRA2, GABRG1 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum, hypothalamus, nucleus.accumbens |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6D6T (EM 3.80A ) 6D6U (EM 3.80A ) 6HUG (EM 3.10A ) 6HUJ (EM 3.04A ) 6HUK (EM 3.69A ) 6HUO (EM 3.26A ) 6HUP (EM 3.58A ) 6I53 (EM 3.20A ) 6X3S (EM 3.12A ) 6X3T (EM 2.55A ) 6X3U (EM 3.49A ) 6X3V (EM 3.50A ) 6X3W (EM 3.30A ) 6X3X (EM 2.92A ) 6X3Z (EM 3.23A ) 6X40 (EM 2.86A ) 7T0W (EM 3.00A ) 7T0Z (EM 3.00A ) 8DD2 (EM 2.90A ) 8DD3 (EM 2.90A ) |
| DBSNP | rs112894280 rs121909673 rs587777365 rs796052505 rs267606837 rs796052508 rs397514737 rs796052510 rs121909672 rs1554100923 rs17855003 |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2538761, ECO:0000269|PubMed:27864268}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508}. |
| Mouse PG classification | HPG |
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