| Gene Information | |
|---|---|
| Gene Name | TRIM21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 475 |
| Protein Names | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000132109 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P19474 |
| Gene Card | TRIM21 |
| Uniprot ID | P19474 |
| Pfam | PF13765; PF00622; PF00643; PF00097 |
| In ASD | no |
| Allosteric Prediction | no (-0.216225488) |
| Ortholog in Animals | Alpaca_ TRIM21 ( ortholog_one2one ) Dog_ TRIM21 ( ortholog_one2one ) GuineaPig_ TRIM21 ( ortholog_one2one ) Macaque_ TRIM21 ( ortholog_one2one ) Mouse_ Trim21 ( ortholog_one2one ) Pig_ TRIM21 ( ortholog_one2one ) Rat_ Trim21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001860(Rat);0.024(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IWG (X-ray 2.35A ) 5JPX (NMR - ) 5OLM (X-ray 1.95A ) 6FGA (X-ray 2.82A ) 6S53 (X-ray 2.80A ) 7BBD (X-ray 2.20A ) |
| DBSNP | rs1042302 rs58403334 rs2975162 rs2554934 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:26347139}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26347139}. Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm, P-body {ECO:0000269|PubMed:18361920}. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies. |
| Mouse PG classification | NA |
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