| Gene Information | |
|---|---|
| Gene Name | AGO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 859 |
| Protein Names | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000123908 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UKV8 |
| Gene Card | AGO2 |
| Uniprot ID | Q9UKV8 |
| Pfam | PF08699; PF16488; PF16487; PF16486; PF02170; PF02171 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999953102) |
| Ortholog in Animals | Alpaca_ AGO2 ( ortholog_one2one ) Dog_ AGO2 ( ortholog_one2one ) GuineaPig_ AGO2 ( ortholog_one2one ) Macaque_ AGO2 ( ortholog_one2one ) Mouse_ Ago2 ( ortholog_one2one ) Pig_ AGO2 ( ortholog_one2one ) Rat_ Ago2 ( ortholog_one2one ) Rabbit_ AGO2 ( ortholog_one2one ) |
| Ohnologs | AGO1, AGO3, AGO4 |
| Paralogs | AGO4, AGO1, AGO3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3LUC (X-ray 1.69A ) 3LUD (X-ray 2.10A ) 3LUG (X-ray 1.85A ) 3LUH (X-ray 2.00A ) 3LUJ (X-ray 1.80A ) 3LUK (X-ray 1.70A ) 3QX8 (X-ray 2.30A ) 3QX9 (X-ray 2.00A ) 4F3T (X-ray 2.25A ) 4OLA (X-ray 2.30A ) 4OLB (X-ray 2.90A ) 4W5N (X-ray 2.90A ) 4W5O (X-ray 1.80A ) 4W5Q (X-ray 3.10A ) 4W5R (X-ray 2.50A ) 4W5T (X-ray 2.50A ) 4Z4C (X-ray 2.30A ) 4Z4D (X-ray 1.60A ) 4Z4E (X-ray 1.80A ) 4Z4F (X-ray 2.80A ) 4Z4G (X-ray 2.70A ) 4Z4H (X-ray 2.50A ) 4Z4I (X-ray 2.80A ) 5JS1 (X-ray 2.50A ) 5JS2 (X-ray 2.95A ) 5KI6 (X-ray 2.15A ) 5T7B (X-ray 2.53A ) 5WEA (X-ray 3.12A ) 6CBD (X-ray 2.20A ) 6MDZ (X-ray 3.40A ) 6MFN (X-ray 2.50A ) 6MFR (X-ray 3.60A ) 6N4O (X-ray 2.90A ) 6NIT (X-ray 3.80A ) 6RA4 (X-ray 1.90A ) 7C6B (X-ray 1.70A ) 7D7U (X-ray 2.00A ) 7KI3 (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:23603119, ECO:0000269|PubMed:33199684}. Nucleus {ECO:0000269|PubMed:23125361}. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. |
| Mouse PG classification | NA |
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