| Gene Information | |
|---|---|
| Gene Name | ACTL7A |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | Actin-like protein 7A (Actin-like-7-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000187003 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y615 |
| Gene Card | ACTL7A |
| Uniprot ID | Q9Y615 |
| Pfam | PF00022; PF16840 |
| In ASD | no |
| Allosteric Prediction | no (-1.290683697) |
| Ortholog in Animals | Alpaca_ ACTL7A ( ortholog_one2one ) Dog_ ACTL7A ( ortholog_one2one ) GuineaPig_ ACTL7A ( ortholog_one2one ) Macaque_ ACTL7A ( ortholog_one2one ) Mouse_ Actl7a ( ortholog_one2one ) Pig_ ACTL7A ( ortholog_one2one ) Rat_ Actl7a ( ortholog_one2one ) Rabbit_ ACTL7A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACTC1, ACTBL2, ACTR1A, ACTB, ACTG1, ACTR5, ACTL9, ACTR3, ACTL7B, ACTL8, ACTA1, ACTL6B, ACTR3B, ACTR3C, ACTRT2, ACTR8, ACTR1B, ACTL6A, ACTR2, ACTR6, ACTRT1, ACTRT3, ACTL10, ACTG2, ACTA2, ACTR10 |
| Tissue | testis |
| Tissue Specificity | Strongly expressed in testis. Also expressed in other tissues. {ECO:0000269|PubMed:10373328}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XQN (X-ray 2.62A ) |
| DBSNP | rs368653764 rs35995497 rs371671871 rs7872077 rs56031956 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32923619}. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}. |
| Mouse PG classification | NA |
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