| Gene Information | |
|---|---|
| Gene Name | ITCH |
| Organism | Homo sapiens (Human) |
| Gene Length | 903 |
| Protein Names | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000078747 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96J02 |
| Gene Card | ITCH |
| Uniprot ID | Q96J02 |
| Pfam | PF00168; PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.028250039) |
| Ortholog in Animals | Alpaca_ ITCH ( ortholog_one2one ) Dog_ ITCH ( ortholog_one2one ) GuineaPig_ ITCH ( ortholog_one2one ) Macaque_ ITCH ( ortholog_one2one ) Mouse_ Itch ( ortholog_one2one ) Pig_ ITCH ( ortholog_one2one ) Rat_ Itch ( ortholog_one2one ) Rabbit_ ITCH ( ortholog_one2one ) |
| Ohnologs | WWP1, WWP2 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DMV (NMR - ) 2KYK (NMR - ) 2NQ3 (X-ray 1.80A ) 2P4R (X-ray 2.00A ) 2YSF (NMR - ) 3TUG (X-ray 2.27A ) 4ROF (X-ray 2.03A ) 5C7M (X-ray 3.03A ) 5CQ2 (X-ray 1.40A ) 5DWS (X-ray 1.65A ) 5DZD (X-ray 1.57A ) 5SXP (X-ray 1.65A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14602072}; Peripheral membrane protein {ECO:0000305|PubMed:14602072}; Cytoplasmic side {ECO:0000305|PubMed:14602072}. Cytoplasm {ECO:0000269|PubMed:14602072}. Nucleus {ECO:0000269|PubMed:20858735}. Early endosome membrane {ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:14602072, ECO:0000305|PubMed:23146885, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:14602072, ECO:0000305|PubMed:23146885, ECO:0000305|PubMed:24790097}. Endosome membrane {ECO:0000269|PubMed:23146885}; Peripheral membrane protein {ECO:0000305|PubMed:23146885}; Cytoplasmic side {ECO:0000305|PubMed:23146885}. Note=May be recruited to exosomes by NDFIP1 (PubMed:18819914). Localizes to plasma membrane upon CXCL12 stimulation where it co-localizes with CXCL4 (PubMed:14602072). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with DTX3L and CXCL4 (PubMed:24790097). {ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:18819914, ECO:0000269|PubMed:24790097}. |
| Mouse PG classification | LPG |
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