| Gene Information | |
|---|---|
| Gene Name | GAB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 676 |
| Protein Names | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000033327 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UQC2 |
| Gene Card | GAB2 |
| Uniprot ID | Q9UQC2 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | yes (0.377778138) |
| Ortholog in Animals | Alpaca_ GAB2 ( ortholog_one2one ) Dog_ GAB2 ( ortholog_one2one ) GuineaPig_ GAB2 ( ortholog_one2one ) Macaque_ GAB2 ( ortholog_one2one ) Mouse_ Gab2 ( ortholog_one2one ) Pig_ GAB2 ( ortholog_one2one ) Rat_ Gab2 ( ortholog_one2one ) Rabbit_ GAB2 ( ortholog_one2one ) |
| Ohnologs | GAB3, GAB1 |
| Paralogs | GAB3, PHLDB2, PHLDB3, GAB1, GAB4, PHLDB1, PLEKHS1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2VWF (X-ray 1.58A ) 2W0Z (X-ray 1.70A ) 5EWZ (X-ray 2.34A ) 5EXA (X-ray 1.95A ) 6Y3R (X-ray 1.50A ) 6Y3S (X-ray 1.95A ) 6ZVB (X-ray 2.51A ) 6ZVC (X-ray 2.51A ) 6ZVD (X-ray 2.50A ) 6ZVE (X-ray 2.51A ) |
| DBSNP | rs752597583 rs2279374 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19172738}. Cell membrane {ECO:0000269|PubMed:19172738}. |
| Mouse PG classification | NA |
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