| Gene Information | |
|---|---|
| Gene Name | PUMA |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BXH1 |
| Gene Card | BBC3 |
| Uniprot ID | Q9BXH1 |
| Pfam | PF15826 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11463391}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2M04 (NMR - ) 4BPI (X-ray 1.98A ) 4BPJ (X-ray 1.60A ) 4BPK (X-ray 1.76A ) 4HNJ (X-ray 2.90A ) 5UUL (X-ray 1.33A ) 6QFM (X-ray 2.00A ) 6QG8 (X-ray 1.90A ) 6TQP (X-ray 1.85A ) 7DVD (X-ray 2.59A ) 7P0S (X-ray 2.50A ) 7P9W (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release. |
| Mouse PG classification | NA |
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