| Gene Information | |
|---|---|
| Gene Name | GA |
| Organism | Homo sapiens (Human) |
| Gene Length | 602 |
| Protein Names | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UI32 |
| Gene Card | GLS2 |
| Uniprot ID | Q9UI32 |
| Pfam | PF12796; PF17959; PF04960 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|PubMed:20378837}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BQM (X-ray 2.18A ) 5U0K (X-ray 2.55A ) |
| DBSNP | rs2657879 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:20378837}. |
| Mouse PG classification | NA |
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