| Gene Information | |
|---|---|
| Gene Name | G3BP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 466 |
| Protein Names | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000145907 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13283 |
| Gene Card | G3BP1 |
| Uniprot ID | Q13283 |
| Pfam | PF02136; PF00076 |
| In ASD | no |
| Allosteric Prediction | yes (0.155399638) |
| Ortholog in Animals | Alpaca_ G3BP1 ( ortholog_one2one ) Dog_ G3BP1 ( ortholog_one2one ) GuineaPig_ G3BP1 ( ortholog_one2one ) Macaque_ G3BP1 ( ortholog_one2one ) Mouse_ G3bp1 ( ortholog_one2one ) Pig_ G3BP1 ( ortholog_one2one ) Rat_ G3bp1 ( ortholog_one2many ) Rat_ AABR07061614.1 ( ortholog_one2many ) |
| Ohnologs | G3BP2 |
| Paralogs | G3BP2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001139(Rat);0.011594(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3Q90 (X-ray 1.70A ) 4FCJ (X-ray 1.62A ) 4FCM (X-ray 2.69A ) 4IIA (X-ray 3.30A ) 5FW5 (X-ray 1.92A ) 6TA7 (X-ray 1.93A ) 7SUO (X-ray 2.35A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:30510222}. Perikaryon {ECO:0000250|UniProtKB:P97855}. Cytoplasm, Stress granule {ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:30404792}. Nucleus {ECO:0000269|PubMed:11604510}. Note=Cytoplasmic in proliferating cells (PubMed:11604510). Cytosolic and partially nuclear in resting cells (PubMed:11604510). Recruited to stress granules in response to arsenite treatment (PubMed:12642610, PubMed:20180778). The unphosphorylated form is recruited to stress granules (PubMed:12642610). HRAS signaling contributes to this process by regulating G3BP dephosphorylation (PubMed:12642610). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |