| Gene Information | |
|---|---|
| Gene Name | G3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1132 |
| Protein Names | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P46379 |
| Gene Card | BAG6 |
| Uniprot ID | P46379 |
| Pfam | PF12057; PF00240 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed by immature dendritic cells (at protein level). {ECO:0000269|PubMed:18852879}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WX9 (NMR - ) 2N9P (NMR - ) 4DWF (X-ray 1.80A ) 4EEW (X-ray 1.30A ) 4WWR (X-ray 2.00A ) 4X86 (X-ray 1.85A ) 6AU8 (X-ray 1.80A ) 7RU9 (EM 3.30A ) 7RUA (EM 3.40A ) 7RUC (EM 3.60A ) |
| DBSNP | rs1052486 rs11548856 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515}. Nucleus {ECO:0000269|PubMed:14960581, ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515}. Secreted, extracellular exosome {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}. Note=Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells (PubMed:18055229, PubMed:18852879). Cytoplasmic retention is due to interaction with GET4 (PubMed:29042515). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879, ECO:0000269|PubMed:29042515}. |
| Mouse PG classification | NA |
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