| Gene Information | |
|---|---|
| Gene Name | G21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96NT5 |
| Gene Card | SLC46A1 |
| Uniprot ID | Q96NT5 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at highest level in the upper half of the small intestine (duodenum and jejunum), expression decreases downwardly in the subsequent quarter and is undetectable in the last quarter (the lowest ileum) (PubMed:17129779, PubMed:19762432). Also expressed in kidney, liver, placenta, spleen, retina and retinal pigment epithelium (PubMed:17129779, PubMed:17335806). Lower levels found in testis (PubMed:17129779). Very low levels in brain, lung, stomach, heart and muscle (PubMed:17129779). {ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17335806, ECO:0000269|PubMed:19762432}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs80338770 rs80338770 rs80338771 rs281875210 rs34552966 rs80338772 rs281875208 rs281875209 rs281875211 rs80338773 rs80338774 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17156779, ECO:0000269|PubMed:17446347, ECO:0000269|PubMed:18405659, ECO:0000269|PubMed:23601781, ECO:0000269|PubMed:25053408, ECO:0000269|PubMed:25504888, ECO:0000269|PubMed:29344585, ECO:0000269|PubMed:30858177, ECO:0000269|PubMed:34619546}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Apical cell membrane {ECO:0000269|PubMed:16143108, ECO:0000269|PubMed:17129779, ECO:0000269|PubMed:17475902}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Basolateral cell membrane {ECO:0000269|PubMed:19074442}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Endosome membrane {ECO:0000305|PubMed:19074442}; Multi-pass membrane protein {ECO:0000269|PubMed:25053408}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442). {ECO:0000250|UniProtKB:Q6PEM8, ECO:0000269|PubMed:19074442}. |
| Mouse PG classification | NA |
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