| Gene Information | |
|---|---|
| Gene Name | ATF7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A) |
| Target Name | activator protein 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000170653 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P17544 |
| Gene Card | ATF7 |
| Uniprot ID | P17544 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | no (-1.120043666) |
| Ortholog in Animals | Alpaca_ ATF7 ( ortholog_one2one ) Dog_ ATF7 ( ortholog_one2one ) GuineaPig_ ATF7 ( ortholog_one2one ) Macaque_ ATF7 ( ortholog_one2one ) Mouse_ Atf7 ( ortholog_one2one ) Pig_ ATF7 ( ortholog_one2one ) Rat_ Atf7 ( ortholog_one2one ) Rabbit_ ATF7 ( ortholog_one2one ) |
| Ohnologs | ATF2 |
| Paralogs | ATF2, CREB5 |
| Tissue | NA |
| Tissue Specificity | Expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. {ECO:0000269|PubMed:8288576}.; [Isoform 4]: Strongly expressed in skeletal muscle. Also expressed at lower levels in heart and lung. {ECO:0000269|PubMed:8288576}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.388808(Rat);0.113624(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17264123}. Chromosome, telomere {ECO:0000269|PubMed:29490055}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:21858082}. |
| Mouse PG classification | NA |
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